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Lipstatin: Fermentative Production - Fermentative Production and Downstream processing of Lipstatin

por Kumar, Maushmi
Condición: Nuevo
47,61 €
IVA incluído - Envío GRATIS
Kumar, Maushmi Lipstatin: Fermentative Production - Fermentative Production and Downstream processing of Lipstatin
Kumar, Maushmi - Lipstatin: Fermentative Production - Fermentative Production and Downstream processing of Lipstatin

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47,61 € incl. IVA
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Entrega: entre viernes, 27 de mayo de 2022 y martes, 31 de mayo de 2022
Ventas y envío: Dodax

Descripción

Streptomyces toxytricini a Gram-positive bacterium belonging to the genus Streptomyces is producer of the pancreatic lipase inhibitor lipstatin,of which the antiobesity drug orlistat is a derivative.The study has been done for optimization of seed media and fermentation media using Plackett-Burman method for increasing the yield of the strain selected.Purification was done on silica gel column and identification of lipstatin molecule using sophisticated techniques such as IR, NMR, and mass spectroscopy. The presence and identification was also confirmed using TLC and HPLC method. This study also compares the impurity profile and the percentage purity of the lipstatin. The optimized media gave a titer of Lipstatin (1980 mg/ml) which is comparable to highest producing benchmarks (2400 mg/ml), but it is quite economical in a way that this work eliminates the use of L-Leucine as media component. The further increase in yield can be tried by different UV, chemical mutation methods in future.

Colaboradores

Autor:
Kumar, Maushmi
Verma, Vikas

Detalles de producto

Biografía del artista:
Maushmi S KumarShobhaben Pratapbhai Patel School of Pharmacy and Technology Management,NMIMS University, Mumbai, INDIAB.Pharm from VNS Inst of Pharmacy in 2003 ,M.Tech in Bio process Technology from Institute of Chemical Technology, Mumbai in 2006.
Idioma:
Inglés
Número de páginas:
80
Tipo de medio:
Tapa blanda
Editorial:
LAP Lambert Academic Publishing

Datos base

Tipo de producto:
Libro de bolsillo
Dimensiones del paquete:
0.22 x 0.15 x 0.005 m; 0.168 kg
GTIN:
09783659148040
DUIN:
QS0F6CUGNPF
47,61 €
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