Pyrazolopyrimidines: Chemical Synthesis and Biological Activity
por Chanda, Kaushik
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Heterocyclic compounds with nitrogen atom play a key role in the normal life cycle of a cell. Pyrazolopyrimidine is a privileged class of nitrogen containing fused heterocyclic compound contributing to a major portion of all lead molecules in medicinal chemistry. The thumbprint of pyrazolopyrimidine as a pharmacophore is always noticeable due to its analogy with the adenine base in DNA. Pyrazolopyrimidines are divided into five types [I, II, III, IV, V] based on the mechanism of action on the specific target conferring a wide scope of research which has accelerated the interest of researchers to investigate its biological profile. In 1956, the anti-cancer activity of pyrazolopyrimidine was evaluated for the first time with appreciable activity. Since then, medicinal chemists centered their work on various methods of synthesis and evaluating the biological profile of pyrazolopyrimidine isomers. This book consists of novel methodologies followed to synthesize pyrazolopyrimidine isomers along with a note on their anticancer activity.
Detalles de producto
Biografía del artista:
Dr Kaushik Chanda is an Assistant Professor in Department of Chemistry, VIT University, Vellore, India. He has published more than 25 international peer-reviewed journal articles and one US patent to his credit. He has delivered invited talks in national and international conferences.
Número de páginas:
Tipo de medio:
LAP Lambert Academic Publishing
Tipo de producto:
Libro de bolsillo
Fecha de aparición:
14 de abril de 2020
Dimensiones del paquete:
0.22 x 0.15 x 0.009 m; 0.272 kg